An MCODE Predicted Complex That is Too Large (Relaxed Parameters) Figure legend: An example of a predicted complex that incorporates two complexes, proteasome (left) and an RNA processing complex (right). These should probably be predicted as separate complexes as can be seen by the clear distinction of biological role annotation on one side of this layout compared to the other (purple versus blue). This figure, however, shows the large amount of overall connectivity between these two complexes. This complex was ranked fourth by MCODE from the predicted complexes in the AllYeast interaction set with slightly relaxed parameters compared to the optimized prediction.
Bader and Hogue BMC Bioinformatics 2003 4:2 doi:10.1186/1471-2105-4-2