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Open AccessResearch article

Total sequence decomposition distinguishes functional modules, "molegos" in apurinic/apyrimidinic endonucleases

Catherine H Schein1 email, Numan Özgün1 email, Tadahide Izumi2 email and Werner Braun1 email

1Sealy Center for Structural Biology, Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston TX 77555-1157, USA

2Sealy Center for Molecular Science, Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston TX 77555-1157, USA

author email corresponding author email

BMC Bioinformatics 2002, 3:37doi:10.1186/1471-2105-3-37

Published: 25 November 2002

Additional files

Additional File 1:

Sequence alignment and MASIA printout for the APE family The original alignment used for the APE family and the MASIA consensus macro output. Note that the A. thaliana sequence is consistently an outlier in the file, due to the CLUSTAL-W misalignment of the nuclease area of the protein when the N-terminal sequence is not removed. The real position of the motifs in the A. thaliana sequence are underlined.

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