Figure 4.

Network models produced by NetSearch. Pathways predicted by NetSearch for (A, B) pheromone response, (C) cell wall integrity, and (D) filamentation pathways, with the starting membrane protein for path drawing (blue), intermediate proteins (green) and transcription factor (red). In each case, the fifteen highest ranked paths between common endpoints were combined to form the signaling network. For the cell wall integrity pathway, the sensor proteins that initiate signal transduction Wsc/1/2/3p and Mid2p did not have any productive interactions. For this pathway, we began our searches at Rho1p and searched for a path length of seven. The size of each vertex is proportional to the sum of the scores of the paths in which it was included. Network graphs were produced with PAJEK graph drawing software [44], http://vlado.fmf.uni-lj.si/pub/networks/pajek webcite.