Histogram of pathways with a given coclustering score for experimental and randomized protein-protein interactions. Histogram of the number of pathways with a given coclustering score for experimental and randomized protein-protein interactions. Shown here is the tail of the distribution with the highest coclustering scores. The paths were drawn with a depth-first search algorithm  from membrane to DNA-binding proteins. It is evident that at high coclustering scores, pathways from the experimentally observed interactions (blue) outnumber those generated from randomized interactions (red – an average of three separate randomizations). The total number of paths for experimental and randomized interaction data (averaged) were within 5% of each other.
Steffen et al. BMC Bioinformatics 2002 3:34 doi:10.1186/1471-2105-3-34