Table 1

Frequency of occurrence of amino acid residues in the eight conserved positions of the LRR-like motifs in the L domains of the IR and EGFR families
Residue
 IR Family (L1 + L2)
 EGFR Family (L1 + L2)


1st
 2nd
 3rd
 4th
 5th
 6th
 7th
 8th
 1st
 2nd
 3rd
 4th
 5th
 6th
 7th
 8th
H
 -
 1
 -
 -
 -
 -
 1
 -
 -
 -
 2
 -
 -
 1
 -
 -
K
 2
 7
 -
 -
 -
 -
 -
 -
 -
 -
 1
 2
 -
 -
 -
 -
R
 -
 -
 -
 -
 -
 1
 -
 -
 -
 -
 2
 -
 3
 1
 -
 -
D
 -
 -
 -
 -
 1
 1
 -
 -
 -
 -
 -
 1
 1
 -
 -
 -
E
 -
 -
 -
 -
 -
 -
 1
 -
 -
 1
 -
 -
 -
 -
 -
 -
N
 -
 9
 -
 68
 -
 -
 2
 -
 -
 -
 -
 61
 -
 -
 -
 -
Q
 -
 -
 1
 -
 -
 2
 -
 -
 1
 2
 3
 3
 2
 2
 -
 -
S
 -
 1
 -
 12
 -
 -
 -
 -
 -
 -
 1
 4
 -
 -
 -
 -
T
 7
 -
 -
 3
 -
 1
 1
 -
 -
 5
 2
 4
 -
 -
 -
 1
P
 1
 -
 -
 -
 1
 -
 -
 -
 -
 -
 -
 -
 -
 -
 -
 -
G
 1
 2
 -
 -
 -
 -
 -
 -
 -
 -
 2
 4
 -
 -
 -
 -
A
 -
 1
 3
 -
 1
 13
 -
 -
 -
 4
 2
 5
 4
 5
 -
 -
V
 17
 20
 26
 12
 13
 4
 2
 13
 35
 35
 24
 6
 15
 13
 6
 10
I
 91
 16
 95
 5
 10
 20
 13
 12
 57
 18
 78
 3
 14
 19
 16
 9
L
 6
 70
 15
 2
 85
 80
 51
 64
 6
 70
 13
 3
 57
 69
 46
 53
M
 1
 9
 2
 14
 3
 -
 9
 1
 -
 5
 5
 1
 7
 5
 13
 -
C
 26
 -
 -
 -
 -
 -
26
 24
 1
 -
 2
 -
 -
 -
 24
F
 2
 7
 13
 1
 11
 4
 39
 -
 10
 1
 8
 -
 8
 4
 28
 -
Y
 1
 -
 1
 -
 5
 4
1
 1
 2
 1
 -
 6
 1
 11
 -
W
 1
 -
 -
 -
 -
 -
13
 -
 -
 -
 8
 1
 -
23

Calculated from conserved positions indicated in Figs 2 &3.

Ward and Garrett BMC Bioinformatics 2001 2:4   doi:10.1186/1471-2105-2-4