Figure 2.

Leucine-rich repeats in the L1 and L2 domain of members of the insulin receptor family. The sequences were sourced from SwissProt except for IR_CAEEL which is GENBANK:AF012437. Residues equivalent to conserved positions 1 to 8 in the sequence motif LxxLxLxxNxLxxLxxLxxLxx are shaded. The INSR_MOUSE is not shown as it differs from INSR_RAT at only S139Y in the 6^th repeat of the L1 domain and S415N in the 4^th repeat of the L2 domain, positions that are not conserved in the LRR motif.