Conserved peptide in RNA directed RNA polymerase. Multiple sequence alignment of the 46 replicase polyprotein 1ab of all coronaviruses revealed that human coronaviruses are conserved in RNA directed RNA polymerase. This alignment was visualized by Jalview 2.8 . Along the alignment this tool provides a graphical (bar chart) conservation summery using 11-base scale for conservancy and BLOSUM 62 for quality. For Conservation yellow color bar and star sign indicates the full conservation. Black bars showed the consensus sequence and yellow color indicates good quality. All the colors changes according to the conservation and alignment quality.
Sharmin and Islam BMC Bioinformatics 2014 15:161 doi:10.1186/1471-2105-15-161