Agreement among disorder sources. The agreement among pairs of disorder data sources is plotted from red (0.0) to green (1.0) using the two definitions local (A) and global (B) agreement from Figure 3. Even though the different sources have a high level of local agreement, the number of times two sources annotate at the same time is relatively low. The global agreement evidences this by showing a drastic drop in agreement when the situation of one of the sources annotating, and the other not, is considered a negative. The MobiDB consensus aims at combining different sources to maximize the coverage when annotating a reference sequence, trying to overcome this issue.
Di Domenico et al. BMC Bioinformatics 2013 14(Suppl 7):S3 doi:10.1186/1471-2105-14-S7-S3