Resolution:
## Figure 3.
The sequence and cluster term sets involved in assessing cluster functional coherence. The sequences in a given domain sequence cluster are associated with different GO
term sets via their parent proteins. Each sequence term set can be split into MF,
BP and CC term subsets. If any of the sequence MF term sets is not empty, a set of
core MF terms for the cluster is compiled from all sequence MF term sets, and, via
further, intermediate steps, a set of terms to be ignored in cluster assessment is
compiled. If none of the sequence term sets contains MF terms, the filter term set
is an empty set. In the next step, the initial cluster term set is prepared as the
union of all representative sequence term sets. From this set, any terms that are
also found in the filter term set are removed (filtered), yielding the final cluster
term set. Like the sequence term sets, the cluster term set can be split into MF,
BP and CC subsets. The term-type specific sets of the representative sequences are
compared with those of the cluster as a whole, respectively, to assess the functional
coherence of the sequences in the cluster. Key term sets in the described process
are highlighted in bold.
Rentzsch and Orengo |