Table 3

Top 20 term associations in category "non-overlap" that were identified by CroGO.

MF Name

BP Name

Evidence


endopeptidase activator activity

proteasome core complex assembly

NEW

TFIIF-class binding TF activity

regulation of histone H3 K79 methylation

NEW

RNA-directed RNA polymerase activity

DNA-dependent transcriptional start site selection

LEXICAL

RNA-directed RNA polymerase activity

transcriptional start site selection at Pol II promoter

LEXICAL

single base insertion or deletion binding

chiasma assembly

REF [26]

double-strand/single-strand DNA junction binding

chiasma assembly

REF [26]

double-stranded telomeric DNA binding

gene conversion at mating-type locus, DNA double-strand break processing

NEW

G-quadruplex DNA binding

gene conversion at mating-type locus, DNA double-strand break processing

NEW

very long-chain fatty acid-CoA ligase activity

long-chain fatty-acyl-CoA metabolic process

REF [27]

very long-chain fatty acid-CoA ligase activity

fatty-acyl-CoA metabolic process

REF [27]

very long-chain fatty acid-CoA ligase activity

acyl-CoA metabolic process

REF [27]

single base insertion or deletion binding

meiotic heteroduplex formation

NEW

guanine/thymine mispair binding

chiasma assembly

NEW

TFIIE-class TF binding

negative regulation of ribosomal protein gene transcription from Pol II promoter in response to chemical stimulus

REF [28]

TFIIE-class binding TF activity

negative regulation of ribosomal protein gene transcription from Pol II promoter in response to chemical stimulus

REF [28]

Hsp90 protein binding

positive regulation of telomere maintenance via telomerase

NEW

Hsp90 protein binding

positive regulation of telomere maintenance

REF [29]

Hsp90 protein binding

positive regulation of homeostatic process

REF [30]

aldehyde dehydrogenase activity

beta-alanine metabolic process

REF [31]

aldehyde dehydrogenase activity

beta-alanine biosynthetic process

REF [31]


Top 20 term associations in category "non-overlap" that were identified by CroGO. In the list, 11 term associations are supported by the existing biological studies, 2 are supported by the lexical matching on term definition, and the rest 7 are new conceptual connections that cannot be found in any literature. None of the term associations can be identified by the VSM or ASR based measures.

Peng et al. BMC Bioinformatics 2013 14(Suppl 2):S15   doi:10.1186/1471-2105-14-S2-S15

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