Table 3 |
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|
Top 20 term associations in category "non-overlap" that were identified by CroGO. |
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|
MF Name |
BP Name |
Evidence |
|
|
||
|
endopeptidase activator activity |
proteasome core complex assembly |
NEW |
|
TFIIF-class binding TF activity |
regulation of histone H3 K79 methylation |
NEW |
|
RNA-directed RNA polymerase activity |
DNA-dependent transcriptional start site selection |
LEXICAL |
|
RNA-directed RNA polymerase activity |
transcriptional start site selection at Pol II promoter |
LEXICAL |
|
single base insertion or deletion binding |
chiasma assembly |
REF [26] |
|
double-strand/single-strand DNA junction binding |
chiasma assembly |
REF [26] |
|
double-stranded telomeric DNA binding |
gene conversion at mating-type locus, DNA double-strand break processing |
NEW |
|
G-quadruplex DNA binding |
gene conversion at mating-type locus, DNA double-strand break processing |
NEW |
|
very long-chain fatty acid-CoA ligase activity |
long-chain fatty-acyl-CoA metabolic process |
REF [27] |
|
very long-chain fatty acid-CoA ligase activity |
fatty-acyl-CoA metabolic process |
REF [27] |
|
very long-chain fatty acid-CoA ligase activity |
acyl-CoA metabolic process |
REF [27] |
|
single base insertion or deletion binding |
meiotic heteroduplex formation |
NEW |
|
guanine/thymine mispair binding |
chiasma assembly |
NEW |
|
TFIIE-class TF binding |
negative regulation of ribosomal protein gene transcription from Pol II promoter in response to chemical stimulus |
REF [28] |
|
TFIIE-class binding TF activity |
negative regulation of ribosomal protein gene transcription from Pol II promoter in response to chemical stimulus |
REF [28] |
|
Hsp90 protein binding |
positive regulation of telomere maintenance via telomerase |
NEW |
|
Hsp90 protein binding |
positive regulation of telomere maintenance |
REF [29] |
|
Hsp90 protein binding |
positive regulation of homeostatic process |
REF [30] |
|
aldehyde dehydrogenase activity |
beta-alanine metabolic process |
REF [31] |
|
aldehyde dehydrogenase activity |
beta-alanine biosynthetic process |
REF [31] |
|
|
||
|
Top 20 term associations in category "non-overlap" that were identified by CroGO. In the list, 11 term associations are supported by the existing biological studies, 2 are supported by the lexical matching on term definition, and the rest 7 are new conceptual connections that cannot be found in any literature. None of the term associations can be identified by the VSM or ASR based measures. |
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|
Peng et al. BMC Bioinformatics 2013 14(Suppl 2):S15 doi:10.1186/1471-2105-14-S2-S15 |
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