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This article is part of the supplement: Selected articles from the Eleventh Asia Pacific Bioinformatics Conference (APBC 2013): Bioinformatics

Open Access Proceedings

Identifying cross-category relations in gene ontology and constructing genome-specific term association networks

Jiajie Peng12, Jin Chen23* and Yadong Wang1*

Author affiliations

1 School of Computer Science and Technology, Harbin Institute of Technology, Harbin, China

2 MSU-DOE Plant Research Laboratory, Michigan State University, East Lansing, MI 48824, USA

3 Department of Computer Science and Engineering, Michigan State University, East Lansing, MI 48824, USA

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Citation and License

BMC Bioinformatics 2013, 14(Suppl 2):S15  doi:10.1186/1471-2105-14-S2-S15

Published: 21 January 2013

Abstract

Background

Gene Ontology (GO) has been widely used in biological databases, annotation projects, and computational analyses. Although the three GO categories are structured as independent ontologies, the biological relationships across the categories are not negligible for biological reasoning and knowledge integration. However, the existing cross-category ontology term similarity measures are either developed by utilizing the GO data only or based on manually curated term name similarities, ignoring the fact that GO is evolving quickly and the gene annotations are far from complete.

Results

In this paper we introduce a new cross-category similarity measurement called CroGO by incorporating genome-specific gene co-function network data. The performance study showed that our measurement outperforms the existing algorithms. We also generated genome-specific term association networks for yeast and human. An enrichment based test showed our networks are better than those generated by the other measures.

Conclusions

The genome-specific term association networks constructed using CroGO provided a platform to enable a more consistent use of GO. In the networks, the frequently occurred MF-centered hub indicates that a molecular function may be shared by different genes in multiple biological processes, or a set of genes with the same functions may participate in distinct biological processes. And common subgraphs in multiple organisms also revealed conserved GO term relationships. Software and data are available online at http://www.msu.edu/~jinchen/CroGO webcite.