|Contribution of each of uBLU’s constraints|
|P-value of the “IFN-gamma pathway”||6.00.10−2||2.05.10−2||2.17.10−1||1.34.10−9|
|P-value of the “IL23-mediated signaling events”||2.60.10−1||8.37.10−2||2.28.10−2||2.18.10−7|
Benefit of constraints in uBLU in terms of gene enrichment in the NCI-curated IFN-gamma and IL23-mediated pathways. As in Tables 6 and 8, the top 200 genes in the inflammatory components, whose scores are shown in Figures 6(a-d), were analyzed using the NCI Pathway Interaction Database. Both positivity and sum-to-one constraints are necessary for uBLU to reveal these two pathways with the high significance (p-value less than 10−6).
Bazot et al.
Bazot et al. BMC Bioinformatics 2013 14:99 doi:10.1186/1471-2105-14-99