(a-c) The AUC analysis of cell types that have high and low confidence of deconvolved gene expression profile. Eosinophil and myeloid dendritic cells have the best AUC scores since these two cell types have the highest proportions in the mixed samples. Naïve B-cells and basophils yield poor but still informative AUC scores, as these two cell types have the lowest frequency in the mixed samples. (d) The plot of mean square of error (MSE) and weight against signal-to-noise ratio (SNR). The best cut-off point was observed around 45. Cell types that are present at too low of a frequency in a given tissue will have dramatically increased errors.
Zhong et al. BMC Bioinformatics 2013 14:89 doi:10.1186/1471-2105-14-89