Unbiased estimation of tissue type specific profiles. (a) Mixing proportions were estimated using markers for liver, brain and lung. DSA estimation can recapitulate the true percentage of each cell type in the mixture. (b-d) DSA estimation of liver, brain and lung gene expression profiles compared against true expression profiles measured using pure tissue samples. (e-f) ROC analysis on differential gene expression analysis of brain vs. liver and lung vs. liver using DSA.
Zhong et al. BMC Bioinformatics 2013 14:89 doi:10.1186/1471-2105-14-89