Open Access Highly Accessed Research article

Elucidating the crosstalk mechanism between IFN-gamma and IL-6 via mathematical modelling

Yun-feng Qi1, Yan-xin Huang1*, Hong-yan Wang1, Yu Zhang1, Yong-li Bao1, Lu-guo Sun1, Yin Wu1, Chun-lei Yu1, Zhen-bo Song1, Li-hua Zheng1, Ying Sun1, Guan-nan Wang1 and Yu-xin Li2*

Author Affiliations

1 National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, 130024, Changchun, China

2 Research Center of Agriculture and Medicine Gene Engineering of Ministry of Education, Northeast Normal University, 130024, ChangChun, China

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BMC Bioinformatics 2013, 14:41  doi:10.1186/1471-2105-14-41

Published: 6 February 2013

Additional files

Additional file 1:

This file contains one figure, nine tables, and description of the biochemical reactions in the crosstalk model and the non-competitive model. Figure S1 shows the overall structure of the crosstalk model. Table S1 lists the parameters and values of the newly added reactions in the crosstalk model. Table S2 lists the parameters and values of the IFN-gamma part of the crosstalk model. Table S3 lists the parameters and values of the IL-6 part of the crosstalk model. Table S4 lists the state variables of the model and their initial values. Table S5 lists the re-estimated parameters and their values in the non-competitive model. Table S6 lists the results of the sensitivity analysis for variations in the concentrations of the pathway components in the competition model. Table S7 lists the results of the sensitivity analysis for variations in the kinetic parameters in the competition model. Table S8 lists the results of the sensitivity analysis for variations in the concentrations of pathway components in the non-competitive model. Table S9 lists the results of the sensitivity analysis for variations in the kinetic parameters in the non-competitive model. All of the biochemical reactions investigated in this study are described in this file, which contains the newly added biochemical reactions, the IFN-gamma and IL-6 parts of the crosstalk model, and the newly added reactions in the non-competitive model.

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Open Data

Additional file 2:

This file contains the crosstalk model and the non-competitive model written in COPASI, which can be executed using COPASI version 4.7.

Format: ZIP Size: 41KB Download file

Open Data