Table 6 |
|||
| In vivo probe inhibitors/inducers/substrates of CYP enzymes | |||
| CYP enzymes | Inhibitors | Inducers | Substrates |
| CYP1A2 | Ciprofloxacin, enoxacin, fluvoxamine, Methoxsalen, mexiletine, oral contraceptives, phenylpropanolamine, thiabendazole, vemurafenib, zileuton, acyclovir, allopurinol, caffeine, cimetidine, daidzein, disulfiram, Echinacea, famotidine, norfloxacin, propafenone, propranolol, terbinafine, ticlopidine, verapamil | Montelukast, phenytoin, smokers versus non-smokers, moricizine, omeprazole, phenobarbital | Alosetron, caffeine, duloxetine, melatonin, ramelteon, tacrine, tizanidine, theophylline, tizanidine |
| CYP2B6 | Clopidogrel, ticlopidine prasugrel | Efavirenz, rifampin, nevirapine | Bupropion, efavirenz |
| CYP2C8 | Gemfibrozil, fluvoxamine, ketoconazole, trimethoprim | Rifampin | Repaglinide, Paclitaxel |
| CYP2C9 | Amiodarone, fluconazole, miconazole, oxandrolone, capecitabine, cotrimoxazole, etravirine, fluvastatin, fluvoxamine, metronidazole, sulfinpyrazone, tigecycline, voriconazole, zafirlukast | Carbamazepine, rifampin, aprepitant, bosentan, phenobarbital, St. John’s wort | Celecoxib, Warfarin, phenytoin |
| CYP2C19 | Fluconazole, fluvoxamine, ticlopidine, esomeprazole, fluoxetine, moclobemide, omeprazole, voriconazole, allicin (garlic derivative), armodafinil, carbamazepine, cimetidine, etravirine, human growth hormone (rhGH), felbamate, ketoconazole, oral contraceptives | Rifampin, artemisinin | Clobazam, lansoprazole, omeprazole, Smephenytoin, S-mephenytoin |
| CYP3A | Boceprevir, clarithromycin, conivaptan, grapefruit juice, indinavir, itraconazole, | Avasimibe, carbamazepine, phenytoin, rifampin, St. John’s wort, bosentan, efavirenz, etravirine, modafinil, nafcillin, amprenavir, aprepitant, armodafinil, clobazamechinacea, pioglitazone, prednisone, rufinamide, vemurafenib | Alfentanil, aprepitant, budesonide, buspirone, conivaptan, darifenacin, darunavir, dasatinib, dronedarone, eletriptan, eplerenone, everolimus, felodipine, indinavir, fluticasone, lopinavir, lovastatin, lurasidone, maraviroc, midazolam, nisoldipine, quetiapine, saquinavir, sildenafil, simvastatin, sirolimus, tolvaptan, tipranavir, triazolam, ticagrelor, vardenafil, Alfentanil, astemizole, cisapride, cyclosporine, dihydroergotamine, ergotamine, fentanyl, pimozide, quinidine, sirolimus, tacrolimus, terfenadine |
| ketoconazole, lopinavir/ritonavir, mibefradil, nefazodone, nelfinavir, posaconazole, ritonavir, saquinavir, telaprevir, telithromycin, voriconazole, amprenavir, aprepitant, atazanavir, ciprofloxacin, crizotinib, darunavir/ritonavir, diltiazem, erythromycin, fluconazole, fosamprenavir, grapefruit juice, imatinib, verapamil, alprazolam, amiodarone, amlodipine, atorvastatin, bicalutamide, cilostazol, cimetidine, cyclosporine, fluoxetine, fluvoxamine, ginkgo, goldenseal, isoniazid, lapatinib, nilotinib, oral contraceptives, pazopanib, ranitidine, ranolazine, tipranavir/ritonavir, ticagrelor, zileuton | |||
| CYP2D6 | Bupropion, fluoxetine, paroxetine, quinidine, cinacalcet, duloxetine, terbinafine, | NA | Atomoxetine, desipramine, dextromethorphan, metoprolol, nebivolol, perphenazine, tolterodine, venlafaxine, Thioridazine, pimozide |
| amiodarone, celecoxib, clobazam, cimetidine, desvenlafaxine, diltiazem, diphenhydramine, echinacea, escitalopram, febuxostat, gefitinib, hydralazine, hydroxychloroquine, imatinib, methadone, oral contraceptives, pazopanib, propafenone, ranitidine, ritonavir, sertraline, telithromycin, verapamil, vemurafenib | |||
Wu et al. BMC Bioinformatics 2013 14:35 doi:10.1186/1471-2105-14-35
