The high-level flow chart of our proposed region-based progressive localization method. In this example, the cell nuclei and clusters are first extracted during initial segmentation with contrast-enhanced salient region detector, then missed or falsely detected cell nuclei are further processed in decluster processing with classification-based candidate identification and probability estimation via distance profile for candidate validation, and better contour delineation is finally achieved with regional contrast-based graphical model. For easier viewing, a quadrant of the original image is shown here, and similarly for Figure 3 and 4. The meaning of the color coding is described in Figures 3, 4 and 5.
Song et al. BMC Bioinformatics 2013 14:173 doi:10.1186/1471-2105-14-173