Table 4

xMSanalyzer doubles the number of features detected in human patient population
Parameter AE column C18 column
12,0.5 (default) 6538 4337
MMCD: 2412 MMCD: 1556
3,0.3 14004 10729
MMCD: 4206 MMCD:2795
3,0.8 10837 8069
MMCD: 3624 MMCD:2367
3,0.3 υ 3,0.8 15955 9396
(xMSanalyzer) MMCD: 5579 MMCD: 2819

Dialysis patients are highly susceptible to environmental chemicals due to repeated exposures to pharmaceuticals, water, and plastics during dialysis sessions. A dataset from 10 plasma samples collected in dialysis patients, each with 2 analytical replicates, were analyzed by xMSanalyzer (at min.exp = 2) and resulted in a >2-fold increase in feature detection (from 6538 to 15955 features on the AE column), in which most m/z are unmatched in the metabolomics database MMCD.

Uppal et al.

Uppal et al. BMC Bioinformatics 2013 14:15   doi:10.1186/1471-2105-14-15

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