Top 10 routes from glucose to pyruvate obtained using CMPF with dynamic penalties. Paths predicted using CMPF with dynamic penalties deviate the least from the native path highlighted in red compared to other methods. As compared to using constant penalties, using dynamic penalties may permit a switch if the species/pathways involved in the switch are similar to each other. Dynamic penalties can also differentiate two paths with equal number of switches.
Lim and Wong BMC Bioinformatics 2012 13(Suppl 17):S17 doi:10.1186/1471-2105-13-S17-S17