An example of decomposing a large cluster based on cell cycle phases. We decomposed a cluster (containing Cdc28) predicted from the PPI network by incorporating cell cycle phase labels of proteins. This helped to identify the different time-based Cdc28-cyclin complexes. These were validated using the Wodak catalogue .
Srihari and Leong BMC Bioinformatics 2012 13(Suppl 17):S16 doi:10.1186/1471-2105-13-S17-S16