Figure 1.

Protein expression discretization. For each protein, we calculate the cell cycle phase in which the protein shows peak expression by averaging over multiple gene expression datasets. We call this procedure as Protein Expression Discretization (PED). We take the aid of Cyclebase [22] for this discretization procedure. If a protein is expressed maximum in more than one phase, it is labeled 'static', else it is labeled 'dynamic' along with the phase in which it expresses maximum. Out of the considered 6114 yeast proteins, 5514 were labeled 'static', and the remaining 600 as 'dynamic'. Out of these 'dynamic' proteins, 576 had distinct a peak phase, while the remaining 24 were labeled 'uncertain'.

Srihari and Leong BMC Bioinformatics 2012 13(Suppl 17):S16   doi:10.1186/1471-2105-13-S17-S16