Resolution:
standard / ## Figure 9.
Semiparametric fits with dynamically estimated coefficients. Semiparametric fits of the distributions of scores for correct and incorrect identifications
on the Controlled Mixture Dataset from a constrained search (tryptic peptides, narrow
mass tolerance) using fixed discriminant coefficients (left) versus adaptive discriminant
coefficients (center). The right tail of the distribution of scores for incorrect
identifications can be seen penetrating the distribution of scores for correct identifications
more deeply in the fixed case implying greater discriminative ability when using the
adaptive discriminant function. The improved performance of adaptive coefficients
can be seen in the plot of the estimated FDR versus the estimated number of significant
correctly identified spectra (right). Recall that in this dataset, target scores are
assumed correct. The estimated FDR here was estimated by the ratio of the number of
decoys to target scores.
Ma |