Simulation of Model 2. The time unit is the week. The time separating a screenshot from the previous one is 10 weeks. The parameters of the model are listed in Table 1. The initial diameter of the tumor ellipsoid is 3 mm. Screenshot number "0" is the state of the tumor after 10 weeks of treatment. In this model, in the spatial domain of tumor lesion, a mesh hosts both healthy and tumor cells. The number of tumor cells is 100 per mesh and the rate of glucose uptake is two order of magnitude smaller than in rate of glucose uptake in Model 1. As in Figure 1, blue regions are those occupied by more that 2000 tumor cells, yellow regions corresponds to areas of tissue with a number of tumor cells between 100 and 2000, and orange regions are those occupied by less that 100 tumor cells. The size of the tumor is approximately constant, but filaments of tumor cells propagate from the border of the tumor.
Lecca and Morpurgo BMC Bioinformatics 2012 13(Suppl 14):S14 doi:10.1186/1471-2105-13-S14-S14