Table 1

Human sequences annotated with human structural templates

Cluster (#)

PDB

(#)

Cluster RMSD (Å)

Template sequence

(#)

Annotated sequence

(#)

Newly annotated sequence (#)

Annotated sequence (ID<30%)*


$

^

°

Mg

8

1

0

9

-

9

55

54

1

Mg and Ions

7

1

0

9

0.30

8

53

52

6

Mg and Ligands

24

4

2

73

0.77

32

159

158

33

Mg , Ions and Ligands

22

5

4

57

0.52

31

1948

1947

19

Mixed

22

6

4

366

0.68

92

473

455

120

Total

83

17

10

514

172

2688

2666

179


Human sequences that inherit annotation from human structural templates are listed as a function of the different typologies of magnesium binding in the PDB files. The table lists the number of clusters, of structural templates, of annotated sequences (sequences that inherit Mg binding positions) according to our procedure, of sequences never annotated before as Mg binding proteins according to UniProtKB and of *sequences annotated when the target/template identity is below the 30%. Three different types of clusters are identified and listed in the first column: $ cluster with structures binding MG with a recognized functional role and whit an EC number, ^ clusters with structures binding MG with a recognized structural role (without an EC number), ° cluster containing structures (119 out of 1,341) binding MG without recognized physiological role.

Piovesan et al. BMC Bioinformatics 2012 13(Suppl 14):S10   doi:10.1186/1471-2105-13-S14-S10

Open Data