Deriving a multivalent DENV antigen for testing in animals. Designing, producing and testing a multivalent DENV antigen for vaccine use. The protein was able to bind antibodies generated against all four types of DENV, and induced antibodies in a rabbit that recognized wild type proteins from all four types of DENV.
Schein et al. BMC Bioinformatics 2012 13(Suppl 13):S9 doi:10.1186/1471-2105-13-S13-S9