False discovery rate (FDR) and receiver operating characteristic (ROC) for three data sets. (a) and (b) Caltech dataset; (c) and (d) Chiang dataset; (e) and (f) Bullard dataset. Three panels on the left indicate the FDR. FDR (on y-axis) is plotted against the number of most significantly differentially expressed genes (on x-axis). Three panels on the right indicate the ROC. Bi denotes binomial distribution; BB denotes beta-binomial distribution. The line for BB γ = 0 was obtained by setting γ = 0 and optimizing Di. It corresponds to the normal beta-binomial distribution. In (b), the line for BB γ = 0 overlap with the line for BB γ = 0.3.
Cai et al. BMC Bioinformatics 2012 13(Suppl 13):S5 doi:10.1186/1471-2105-13-S13-S5