Proposed mechanism describing the irreversible inhibition of HIV proteinase. The enzyme HIV proteinase (E), which is only active in a dimer form, was added to a solution of an irreversible inhibitor (I) and a fluorogenic substrate (S). The product (P) is a competitive inhibitor for the substrate.
Miró et al. BMC Bioinformatics 2012 13:90 doi:10.1186/1471-2105-13-90