Additional file 3.

Two single-stage designs are compared to the results: For the first single-stage design the sample size for each hypothesis is n1, for the second design the sample size is n1 + n2. For the first design we compare the gain in power of the integrated design and for the second design the attention lies on the reduction in costs.

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Zehetmayer and Posch BMC Bioinformatics 2012 13:81   doi:10.1186/1471-2105-13-81