Table 6

OverlapPlus matching
Step 1
Apply the overlap matching procedure.
Step 2
For all unmatched genes, the closest DNA copy number feature down- and upstream are
determined.
Step 3
Per gene, assess whether any of the samples in the dataset exhibits a breakpoint (i.e., a change in the segmented DNA copy number) in between the genes closest down- and upstream feature. If no breakpoint is present (the top panel of Figure 6), assign the DNA copy number data of the closest feature to the gene. If, any of the samples reveals a breakpoint (the bottom panel of Figure 6), the gene is left unmatched. For it could not be decided whether the closest down- or upstream feature contains the correct DNA copy number data.

van Wieringen et al.

van Wieringen et al. BMC Bioinformatics 2012 13:80   doi:10.1186/1471-2105-13-80

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