|For each gene, calculate the percentage of overlap between its sequence and that of the DNA copy number array features (mapping to the same chromosome as the gene). The percentage of overlap is defined as the number of overlapping base pairs between the two sequences divided by the length of the DNA copy number probe. See the top panel of Figure 5 for an illustration.|
|For each gene, calculate the weighted average of the DNA copy number data of the features (mapping to the same chromosome as the gene). Weights are chosen proportional to the percentage of overlap of the features’ sequence to that of the gene. This is depicted in the bottom panel of Figure 5.|
van Wieringen et al.
van Wieringen et al. BMC Bioinformatics 2012 13:80 doi:10.1186/1471-2105-13-80