|For all genes, calculate their midpoints (average of start and end base pair position). Do the same for the features on DNA copy number array.|
|For each gene, calculate the distance between its midpoint and that of the DNA copy number array features (mapping to the same chromosome as the gene). See the top panel of Figure 3.|
|For each gene, calculate the weighted average of the DNA copy number data of the features (mapping to the same chromosome as the gene). Weights are chosen reciprocal to the distance of the features’ midpoint to that of the gene (bottom panel of Figure 3).|
van Wieringen et al.
van Wieringen et al. BMC Bioinformatics 2012 13:80 doi:10.1186/1471-2105-13-80