Table 4 |
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Domain-domain interaction enrichment | |||||||
Reference set | IDBOS | Hypergeometric | Occurrence | Random rank | |||
Fraction | Gain | Fraction | Gain | Fraction | Gain | Fraction | |
DDI | 0.225 | 48% | 0.215 | 42% | 0.174 | 15% | 0.152 |
The fraction of true domain-domain interactions (DDIs) retrieved with interaction detection based on shuffling (IDBOS), hypergeometric test ranking, occurrence ranking, and randomly ranked data. We calculated the reported fraction and gain associated with the different ranking schemes as outlined in Equations 3 and 4. We tested whether the numerical differences in the fraction values for each pairwise comparison were due to chance using the t-test, and rejected this hypothesis with a p-value of <10^{-24}.
Yu et al.
Yu et al. BMC Bioinformatics 2012 13:79 doi:10.1186/1471-2105-13-79