Figure 1.

Workflow of this study. Initially two similarity matrices of different views were used as input after standardization to the z-value and renormalization. Then a two-step alternative minimization was used to obtain the proper weights for the two similarity matrix in fusion. In the first step, given the initial weights <a onClick="popup('http://www.biomedcentral.com/1471-2105/13/75/mathml/M6','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1471-2105/13/75/mathml/M6">View MathML</a>. cross-entropy between the input matrices and a combined non-negative factorization was minimized by an EM algorithm. In the second step, given the calculated cross-entropy, the weights were calculated by minimizing the object function, i.e. the cross-entropy and entropy of the weight. The two steps iterate until convergence. The final α was used as an ideal weighing vector that obtains balance between weighted sparseness and informativeness.

Xu et al. BMC Bioinformatics 2012 13:75   doi:10.1186/1471-2105-13-75
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