Variation of gene expression correlates with local in vivo nucleosome occupancy and DNA structures. Plotted are the results in the 500 bp region surrounding transcription start sites (TSS) of 5,015 differentially expressed genes. The 5,015 genes were grouped into 3 classes by their expression level (EL): EL <1 (n = 759, black line), 1 ≤ EL <2 (n = 1,859, red line) and EL ≥ 2 (n = 2,397, blue line). (A) Average in vivo nucleosome occupancy. (B) Average structural profiles of DNA denaturation. (C) Average structural profiles of Z-DNA.
Gan et al. BMC Bioinformatics 2012 13:49 doi:10.1186/1471-2105-13-49