Gene fusion in human breast cancer. Extension graph of an extremity of an exon from the VAPB human gene located on chromosome 20. a): the raw graph produced by MAPSEMBLER. b): the same graph manually curated by mapping the sequence of each node on the human genome. Nodes where moved in order to reflect their relative mapping position on the chromosomes. Nodes from the raw graph having sequences mapping at the same position where merged. For each node, the start and stop positions of the mapping are indicated. The presence of two start and stop positions reflects the presence of a central intron. Except for the purple node having multiple hits among the genome, 100% of the sequence of each node was mapped, either to an exon from gene VAPB on chromosome 20 or from gene IKZF3 on chromosome 17. The bold edge corresponds to the gene fusion found in , while the two other edges starting from the starter and targeting a chromosome 17 exon are new gene fusions.
Peterlongo and Chikhi BMC Bioinformatics 2012 13:48 doi:10.1186/1471-2105-13-48