Effect of the transcription factor abundance on the robustness ofE. coliensembles. The robustness (SRR) values of different networks are plotted against a wide range of the number of transcription factors (TF). All the plots are for an ensemble of 1000 networks where the number of transcription factors has been varied retaining the number of nodes and edges of the E.coli reference as constant. SRR values for one node knockout, α = 0.05 and β = 1% for knockout, parametric and initial condition perturbation have been shown. Increasing the number of transcription factors adversely affects both knockout and initial condition robustness, but does not have a significant effect on parametric robustness.
Zamal and Ruths BMC Bioinformatics 2012 13:318 doi:10.1186/1471-2105-13-318