## Table 1 |
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A list of each feature contained within our surface descriptor |
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Feature # |
Name |
Description |

1 | % Visibility | Percentage of outside world visible from point |

2 | Non-Polar Backbone | Distance to the nearest Non-Polar Backbone Atom |

3 | Arom. Sidechain | Distance to the nearest Aromatic Sidechain Atom |

4 | Aliph. Sidechain | Distance to the nearest Aliphatic Sidechain Atom |

5 | N Backbone | Distance to the nearest Nitrogen Backbone Atom |

6 | O Backbone | Distance to the nearest Oxygen Backbone Atom |

7 | S Backbone | Distance to the nearest Sulpher Sidechain Atom |

8 | Amide N Sidechain | Distance to the nearest Amide Nitrogen Sidechain Atom |

9 | Amide O Sidechain | Distance to the nearest Amide Oxygen Sidechain Atom |

10 | Trp Sidechain | Distance to the nearest Trypophan Sidechain Atom |

11 | Hydroxyl Sidechain | Distance to the nearest Hydroxyl Sidechain Atom |

12 | Charged O Sidechain | Distance to the nearest Charged Oxygen Sidechain Atom |

13 | Charged N Sidechain | Distance to the nearest Charged Nitrogen Sidechain Atom |

14 | Anisotropy (1.6 Å) | Patch anisotropy, with radius: 1.6 Å |

15 | Anisotropy (3.2 Å) | Patch anisotropy, with radius: 3.2 Å |

16 | Anisotropy (4.8 Å) | Patch anisotropy, with radius: 4.8 Å |

17 | Anisotropy (6.4 Å) | Patch anisotropy, with radius: 6.4 Å |

18 | Anisotropy (8 Å) | Patch anisotropy, with radius: 8 Å |

19 | Curvature (1.6 Å) | Patch curvature, with radius: 1.6 Å |

20 | Curvature (3.2 Å) | Patch curvature, with radius: 3.2 Å |

21 | Curvature (4.8 Å) | Patch curvature, with radius: 4.8 Å |

22 | Curvature (6.4 Å) | Patch curvature, with radius: 6.4 Å |

23 | Curvature (8 Å) | Patch curvature, with radius: 8 Å |

24 | Curvature Var. (1.6 Å) | Variance of curvature within patch of radius: 1.6 Å |

25 | Curvature Var. (3.2 Å) | Variance of curvature within patch of radius: 3.2 Å |

26 | Curvature Var. (4.8 Å) | Variance of curvature within patch of radius: 4.8 Å |

27 | Curvature Var. (6.4 Å) | Variance of curvature within patch of radius: 6.4 Å |

28 | Curvature Var. (8 Å) | Variance of curvature within patch of radius: 8 Å |

29 | Hydropathy (1.6 Å) | Weighted avg. hydropathy over patch of radius: 1.6 Å |

30 | Hydropathy (3.2 Å) | Weighted avg. hydropathy over patch of radius: 3.2 Å |

31 | Hydropathy (4.8 Å) | Weighted avg. hydropathy over patch of radius: 4.8 Å |

32 | Hydropathy (6.4 Å) | Weighted avg. hydropathy over patch of radius: 6.4 Å |

33 | Hydropathy (8 Å) | Weighted avg. hydropathy over patch of radius: 8 Å |

34 | Charge (1.6 Å) | Weighted avg. charge over patch of radius: 1.6 Å |

35 | Charge (3.2 Å) | Weighted avg. charge over patch of radius: 3.2 Å |

36 | Charge (4.8 Å) | Weighted avg. charge over patch of radius: 4.8 Å |

37 | Charge (6.4 Å) | Weighted avg. charge over patch of radius: 6.4 Å |

38 | Charge (8 Å) | Weighted avg. charge over patch of radius: 8 Å |

39 | Hyd. Bond Donor | Distance to nearest potential external hydrogen bond donor |

40 | Hyd. Bond Acceptor | Distance to nearest potential external hydrogen bond acceptor |

Note that features 14 - 38 are weighted according to distance (from center vertex) and point area (i.e. the sum of the areas of all adjacent triangles).

Cipriano * et al.*

Cipriano * et al.* *BMC Bioinformatics* 2012 **13**:314 doi:10.1186/1471-2105-13-314