Representative cases of new, additional, and shifted ubiquitylation sites. Novel ubiquitylation sites (+) and the surrounding regions for NAGLU (A), BIRC2 (B), and LRPPRC (C) proteins are presented. Ancestrally conserved lysine residues in the LRPPRC protein that disappeared in great apes are highlighted on a gray background. Hash symbols (#) indicate ubiquitylated lysines that were experimentally validated in humans. See Figure 3 for more manipulations.
Kim and Hahn BMC Bioinformatics 2012 13:306 doi:10.1186/1471-2105-13-306