Over-representation of drug targets along a degree rank for Binary (B), N-ary (N) and Spoke-represented (S) interaction types. Proteins were grouped into bins according to their degree. The width of each bin represents the number of proteins in that bin while the height (−log of the p-value of the hypergeometric test) represents how over-represented drug targets are in that bin. Over-represented bins (p-value < 0.05) are highlighted in red. The number of drug targets in each bin is indicated at the top of each bar. Each bin contains at least 200 proteins. Drug targets are over-represented in high-degree bins and some middle-degree bins for the B subset (a), while this trend is largely lost in the N (b) and S (c) data sets.
Mora and Donaldson BMC Bioinformatics 2012 13:294 doi:10.1186/1471-2105-13-294