Figure 1.

The schema of the MR workflow utilizing local model quality. A) The B-factor value of each atom in a search model is modified according to the corresponding deviation. B) The initial placement of a search model in the asymmetric unit is done by AMORE and MOLREP programs, then 10 best scored solutions of each of the programs are selected. C) Then, such solutions are converted to polyalanine models and given as an input to PHASER. D) Next, the top solution of the PHASER program is given as the input to Refmac5 to perform restrained refinement. E) Finally, the structure of the target is built automatically using the ARP/wARP program.

Pawlowski and Bujnicki BMC Bioinformatics 2012 13:289   doi:10.1186/1471-2105-13-289
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