Table 1

Consequence of non-conserved amino acid residues of XCE
ECE-1 XCE Change in Nature Structural features Subsite
R145 T146 Basic to nucleophilic No binding with carboxylate S2’
W146 Y147 Aromaticity conserved Volume of subsite is shrinked S2’
F149 I150 Aromatic to aliphatic Aromatic wall is absent S1’
S150 A151 Nucleophilic to hydrophobic No overall change S2’
W153 G154 Aromatic to small aliphatic Volume of subsite is shrinked S2’
V565 L570 Hydrophobicity conserved H-bond acceptor is conserved NAYY
F587 L592 Aromatic to aliphatic Aromatic wall is absent S1’
V603 T608 Hydrophobic to nucleophilic No overall change S1’
V604 I609 Hydrophobicity conserved More interaction with the P1’ moiety S1’
V713 N718 Hydrophobic to hydrophilic Polarity at the bottom of subsite S1’

Ul-Haq et al.

Ul-Haq et al. BMC Bioinformatics 2012 13:285   doi:10.1186/1471-2105-13-285

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