Effect of imbalanced transcript levels on the posteriors of biallelically expressed genes. Solid lines stand for simulated posteriors for imprinted genes (black line) and biallelically expressed genes (non-black lines). “Randomly imbalanced” means that in each sample we randomly picked one allele to have a lower expression level than the other allele. FIC indicates “Fixed Imbalanced Coefficient”, which means one allele is always expressed at a “FIC” level of the other one in all samples. The dashed line stands for the log-transformed prior. When FIC is low enough (typically <13%), posteriors are not able to tell the difference between imprinted (solid black line) and biallelic expression (green line).
Li et al. BMC Bioinformatics 2012 13:271 doi:10.1186/1471-2105-13-271