SFams are Related Through a Sparse Network. Comparing the similarity between SFams reveals a network of relationships between families. The components that comprise the network tend to have a minimally connected topology, as illustrated by a random sampling of 250 components from the network (A). Here, SFams are represented by dots and lines represent relationships between SFams. Most components are populated by a small number of SFams, as illustrated in the component size distribution (B; log scale). Most components are made up of SFams that share at least one functional annotation, as indicated in the distribution of the fraction of nodes per component that share an annotation label (C).
Sharpton et al. BMC Bioinformatics 2012 13:264 doi:10.1186/1471-2105-13-264