Table 3

The 20 genes in EcoCyc and BsubCyc with the highest influence scores
E. coli K-12 B. subtilis
Gene Product Role Score Direct Targets Gene Product Role Score Direct Targets
rpoD sigma-70 factor 100 2282 sigA sigma-43 factor 100 863
rpoE sigma-24 factor 44 550 sigB sigma-37 factor 75 101
crp cAMP receptor protein 36 465 spo0A response regulator 55 88
lexA SOS response transcriptional repressor 32 56 sigE sporulation-specific sigma-29 factor 51 128
ihfA integration host factor, α-subunit 26 225 spoIVCB sporulation-specific sigma-K factor precursor (N-terminal half) 46 101
ihfB integration host factor, β-subunit 26 225 spoIIIC sporulation-specific sigma-K factor precursor (C-terminal half) 46 101
rpoS sigma-S factor 26 316 spoIIID sporulation-specific transcriptional regulator 46 37
rpoH sigma-32 factor 25 450 gerE transcriptional regulator 34 104
cpxR stress response regulator 23 58 abrB regulator of transition state genes 25 100
fis factor for inversion stimulation 19 223 sigH sigma-30 factor 22 21
gadX acid resistance system regulator 14 28 rok repressor of comK 3 27
fur ferric uptake regulator 13 131 comK competence transcription factor 3 55
arcA anaerobic response regulator 11 160 degU two-component response regulator 1.6 19
hns histone-like nucleoid structuring protein 11 174 codY GTP and BCAA-dependent transcriptional regulator 1.6 63
fnr aerobic to anaerobic transition regulator 10 294 sinR post-exponential phase response regulator 1.6 21
dnaA chromosomal replication initiator protein 8.2 12 med positive regulator of comK 1.6 1
cytR cytidine repressor 8.2 12 scoC extracellular protease production and sporulation regulator 0.8 16
nsrR nitrite-sensitive repressor 6.8 83 senS transcriptional activator 0.8 2
rpoN sigma-54 factor 6.4 179 salA Mrp family regulator 0.4 1
gadE acid resistance system regulator 5.4 36 sigG sporulation-specific sigma-G factor 0.4 84

Paley et al.

Paley et al. BMC Bioinformatics 2012 13:243   doi:10.1186/1471-2105-13-243

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