Figure 3.

Effect of pooling and SNP calling on estimated site frequency spectrum (SFS). The thick black line depicts the true SFS after pooling, but before sequencing, i.e., as if power was 1 and no false discoveries. Boxplots show the estimated SFS after sequencing and SNP calling for reads with exact depth 20. The two best methods are compared: samtools mpileup and snape with informative prior. Results for 100 replicates and N = 100 chromosomes.

Raineri et al. BMC Bioinformatics 2012 13:239   doi:10.1186/1471-2105-13-239
Download authors' original image