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Open Access Research article

Disentangling evolutionary signals: conservation, specificity determining positions and coevolution. Implication for catalytic residue prediction

Elin Teppa1, Angela D Wilkins2, Morten Nielsen34 and Cristina Marino Buslje1*

Author Affiliations

1 Fundación Instituto Leloir, Avda. Patricias Argentinas 435, CABA, C1405BWE, Argentina

2 Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas

3 Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark

4 Instituto de Investigaciones Biotecnológicas, Universidad de San Martín, San Martín, B 1650 HMP, Buenos Aires, Argentina

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BMC Bioinformatics 2012, 13:235  doi:10.1186/1471-2105-13-235

Published: 14 September 2012

Additional files

Additional file 1:

Table S1. Spearman rank correlation between methods and their standard deviation.

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Additional file 2:

Figure S1. Schematic representation of the sequence redundancy impact on ivET predictions.

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Additional file 3:

Figure S2. Distribution of the number of Pfam families vs number of sequences per family.

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Open Data