Table 3

Pathway analysis performed using SPIA statistical test on graphite networks.

Name

FDR

Signal

Database

BCR

ABL


1

Leishmaniasis

0.03

Activated

KEGG

2

Phase 1 - Functionalization of compounds

0.02

Activated

Reactome

3

Syndecan-4-mediated signaling events

0.00

Activated

NCI

4

Regulation of RAC1 activity

0.00

Activated

NCI

5

RAC1 signaling pathway

0.00

Activated

NCI

6

RhoA signaling pathway

0.00

Activated

NCI

7

Regulation of RhoA activity

0.00

Activated

NCI

8

Noncanonical Wnt signaling pathway

0.00

Activated

NCI

9

Wnt signaling network

0.00

Activated

NCI

10

BCR signaling pathway

0.00

Inhibited

NCI

11

IL6-mediated signaling events

0.00

Inhibited

NCI

12

Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

0.00

Inhibited

NCI

13

Stabilization and expansion of the E-cadherin adherens junction

0.00

Activated

NCI

14

E-cadherin signaling in the nascent adherens junction

0.00

Activated

NCI

15

E-cadherin signaling events

0.00

Activated

NCI

16

HIF-1-alpha transcription factor network

0.00

Inhibited

NCI

17

ALK1 signaling events

0.01

Activated

NCI

18

Canonical Wnt signaling pathway

0.02

Activated

NCI

19

ALK1 pathway

0.02

Activated

NCI

20

S1P2 pathway

0.02

Inhibited

NCI

21

Regulation of nuclear SMAD2/3 signaling

0.02

Activated

NCI

22

Regulation of cytoplasmic and nuclear SMAD2/3 signaling

0.02

Activated

NCI

23

TGF-beta receptor signaling

0.02

Activated

NCI

24

C-MYB transcription factor network

0.02

Activated

NCI

25

Osteopontin-mediated events

0.02

Inhibited

NCI

26

Direct p53 effectors

0.02

Inhibited

NCI

27

Validated transcriptional targets of AP1 family members Fra1 and Fra2

0.03

Activated

NCI

28

Regulation of nuclear beta catenin signaling and target gene transcription

0.03

Activated

NCI

29

S1P4 pathway

0.03

Inhibited

NCI

30

amb2 Integrin signaling

0.03

Activated

NCI

31

p38 MAPK signaling pathway

0.04

Activated

NCI

32

Posttranslational regulation of adherens junction stability and dissassembly

0.04

Activated

NCI

33

N-cadherin signaling events

0.04

Activated

NCI

34

Lissencephaly gene (LIS1) in neuronal migration and development

0.05

Activated

NCI

35

C-MYC pathway

0.06

Inhibited

NCI

36

p53 pathway

0.06

Activated

NCI


Sales et al. BMC Bioinformatics 2012 13:20   doi:10.1186/1471-2105-13-20

Open Data