|Comparison with Similar Tools|
|Tool Name||Average Interactions||Background Knowledge||Unique Genes in database||Organisms|
|Genes2FANs||72.1 ± 51||PPI, literature co-occurrence, miRNAs, co-regulation, domains, drug signatures & targets, gene signatures, metabolites, and phenotypes||35,078||H.sapiens, M.musculus, R.norvegicus|
|PIPs||10.1 ± 25.2||Co-expression, orthology, domains, co-localization, and PTMs||5,338||H.sapiens|
|HEFalMp||681.3 ± 1123.2||Functionally mapped data from microarray experiments and sequence comparisons||24,433||H.sapiens|
|GeneMania||78.7 ± 39.2||Co-expression, physical & genetic interactions, domains, co-localization, pathways, and orthology||155,238||H.sapiens, A.thaliana, C.elegans, D.melanogaster, M.musculus, R.norvegicus, and S.cerevisiae|
|STRING 9.0||24.3 ± 14.4||Co-localization, fusion, co-occurrence, co-expression, literature co-occurrence, and orthology||5,214,234||1,133 Organisms|
|FunCoup||47.7 ± 21.9||PPI, orthology, co-expression, miRNA, co-localization, phylogenetics, co-regulation, genetic interactions, and domains||1,800,000||H.sapiens, M.musculus, R.norvegicus, D.melanogaster, A.thaliana, C.elegans, S.cerevisiae,and C.intestinalis|
Comparison of Genes2FANs with five similar tools; examining the average number of interactions returned for single gene queries, the types of background knowledge for each tool, the number of unique genes/proteins in each knowledgebase, and the supported organisms.
Dannenfelser et al.
Dannenfelser et al. BMC Bioinformatics 2012 13:156 doi:10.1186/1471-2105-13-156