Figure 3.

The relationship between false-positive information content and the number of sequences. The figure shows the theoretical upper bound on the information content threshold, D*, when one or more false-positive motif is expected to be observed in a dataset as function of the number of sequences, n (dashed line) compared to the strength of false-positive motifs detected by MEME (crosses). For both cases n is chosen from n = {10,20,30,50,100} and the parameters L = 1000 and W = 10 are fixed. The strength of motifs detected by MEME is consistent with the strength of motifs predicted to occur by chance for the given sample size.

Zia and Moses BMC Bioinformatics 2012 13:151   doi:10.1186/1471-2105-13-151
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