Comparison of EMIM and LEM for Case/Parent Trios. Plots showing the comparison of EMIM and LEM using simulated data for 4000 case/parent trios, assuming R1=1.5 and R2=2.25 at SNP number 1004 and S1=2 and S2=3 at SNP number 6004. Plots of the p-values for each SNP to detect maternal effects given child and imprinting effects by: A: EMIM and B: LEM. Plots of the parameters values for: C: R1; D: R2; E: S1; F: S2; G: Im. H: Plot of the p-values for the alternative (5-parameter) model versus the null (3-parameter) model calculated using EMIM and MENDEL.
Howey and Cordell BMC Bioinformatics 2012 13:149 doi:10.1186/1471-2105-13-149